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The functional neuroanatomy of depression: Distinct roles for ventromedial and dorsolateral prefrontal cortex

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Resource type
Journal Article
Authors/contributors
Title
The functional neuroanatomy of depression: Distinct roles for ventromedial and dorsolateral prefrontal cortex
Abstract
A primary aim in the neuroscientific study of depression is to identify the brain areas involved in the pathogenesis of symptoms. In this review, we describe evidence from studies employing various experimental approaches in humans (functional imaging, lesion method, and brain stimulation) that converge to implicate the ventromedial and dorsolateral sectors of prefrontal cortex as critical neural substrates for depression, albeit with distinct functional contributions. The putative roles of ventromedial and dorsolateral prefrontal cortex in depression are discussed in light of the results.
Publication
Behavioural brain research
Volume
201
Issue
2
Pages
239-243
Date
2009-8-12
Journal Abbr
Behav Brain Res
DOI
10.1016/j.bbr.2009.03.004
ISSN
0166-4328
Short Title
The functional neuroanatomy of depression
URL
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680780/
Accessed
5/7/23, 8:07 PM
Library Catalog
PubMed Central
Extra
PMID: 19428640 PMCID: PMC2680780
Link
Citation
Koenigs, M., & Grafman, J. (2009). The functional neuroanatomy of depression: Distinct roles for ventromedial and dorsolateral prefrontal cortex. Behavioural Brain Research, 201(2), 239–243. https://doi.org/10.1016/j.bbr.2009.03.004
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